UMMS Affiliation

Department of Obstetrics and Gynecology

Publication Date

7-1-2015

Document Type

Article

Disciplines

Female Urogenital Diseases and Pregnancy Complications | Neoplasms | Women's Health

Abstract

Endometriosis is a benign gynecological condition characterized by specific histological, molecular, and clinical findings. It affects 5%-10% of premenopausal women, is a cause of infertility, and has been implicated as a precursor for certain types of ovarian cancer. Advances in technology, primarily the ability for whole genome sequencing, have led to the discovery of new mutations and a better understanding of the function of previously identified genes and pathways associated with endometriosis associated ovarian cancers (EAOCs) that include PTEN, CTNNB1 (beta-catenin), KRAS, microsatellite instability, ARID1A, and the unique role of inflammation in the development of EAOC. Clinically, EAOCs are associated with a younger age at diagnosis, lower stage and grade of tumor, and are more likely to occur in premenopausal women when compared with other ovarian cancers. A shift from screening strategies adopted to prevent EAOCs has resulted in new recommendations for clinical practice by national and international governing bodies. In this paper, we review the common histologic and molecular characteristics of endometriosis and ovarian cancer, risks associated with EAOCs, clinical challenges and give recommendations for providers.

Rights and Permissions

Citation: Int J Womens Health. 2015 Jul 1;7:663-72. doi: 10.2147/IJWH.S66824. eCollection 2015. Link to article on publisher's site

DOI of Published Version

10.2147/IJWH.S66824

Comments

Copyright © 2015 Pavone and Lyttle. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

Related Resources

Link to Article in PubMed

Keywords

clinical, inflammation, molecular, pathways, premenopausal

Journal/Book/Conference Title

International journal of women's health

PubMed ID

26170722

Creative Commons License

Creative Commons Attribution-Noncommercial 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License

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