UMMS Affiliation

Department of Medicine, Division of Cardiovascular Medicine

Publication Date

6-30-2015

Document Type

Article

Disciplines

Endocrinology | Endocrinology, Diabetes, and Metabolism

Abstract

In murine and human brown adipose tissue (BAT), mitochondria are powerful generators of heat that safely metabolize fat, a feature that has great promise in the fight against obesity and diabetes. Recent studies suggest that the actions of mitochondria extend beyond their conventional role as generators of heat. There is mounting evidence that impaired mitochondrial respiratory capacity is accompanied by attenuated expression of Ucp1 and other BAT-selective genes, implying that mitochondria exert transcriptional control over the brown fat gene program. In this review, we discuss the current understanding of brown fat mitochondria, their potential role in transcriptional control of the brown fat gene program, and potential strategies to treat obesity in humans by leveraging thermogenesis in brown adipocytes.

Rights and Permissions

Citation: Front Endocrinol (Lausanne). 2015 Jun 30;6:104. doi: 10.3389/fendo.2015.00104. eCollection 2015. Link to article on publisher's site

DOI of Published Version

10.3389/fendo.2015.00104

Comments

Copyright © 2015 Nam and Cooper. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Related Resources

Link to Article in PubMed

Keywords

brown fat, brown fat gene program, mitochondria, respiratory capacity, thermogenesis

Journal/Book/Conference Title

Frontiers in endocrinology

PubMed ID

26175716

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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