UMMS Affiliation

Department of Pathology

Date

7-1-2015

Document Type

Article

Subjects

Animals; Antigens; Biomarkers; Histocompatibility Antigens; Humans; Receptors, Antigen, T-Cell, alpha-beta; T-Lymphocytes; Thymus Gland

Disciplines

Immunity | Immunopathology | Pathology

Abstract

The diversity of antigen receptors and the specificity it underlies are the hallmarks of the cellular arm of the adaptive immune system. T and B lymphocytes are indeed truly unique in their ability to generate receptors capable of recognizing virtually any pathogen. It has been known for several decades that T lymphocytes recognize short peptides derived from degraded proteins presented by major histocompatibility complex (MHC) molecules at the cell surface. Interaction between peptide-MHC (pMHC) and the T cell receptor (TCR) is central to both thymic selection and peripheral antigen recognition. It is widely assumed that TCR diversity is required, or at least highly desirable, to provide sufficient immune coverage. However, a number of immune responses are associated with the selection of predictable, narrow, or skewed repertoires and public TCR chains. Here, we summarize the current knowledge on the formation of the TCR repertoire and its maintenance in health and disease. We also outline the various molecular mechanisms that govern the composition of the pre-selection, naive and antigen-specific TCR repertoires. Finally, we suggest that with the development of high-throughput sequencing, common TCR 'signatures' raised against specific antigens could provide important diagnostic biomarkers and surrogate predictors of disease onset, progression and outcome.

Rights and Permissions

Citation: Cell Mol Immunol. 2015 Jul;12(4):391-9. doi: 10.1038/cmi.2014.134. Epub 2015 Jan 26. Link to article on publisher's site

DOI of Published Version

10.1038/cmi.2014.134

Comments

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Related Resources

Link to Article in PubMed

Keywords

T cell receptor (TCR), TCR repertoire, TCR diversity, TCR clonotype, TCR bias, Deep sequencing

Journal Title

Cellular and molecular immunology

PubMed ID

25619506

Creative Commons License

Creative Commons Attribution-Noncommercial-Share Alike 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 License.

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