UMMS Affiliation

Department of Pathology

Publication Date

8-5-2015

Document Type

Article

Disciplines

Immune System Diseases | Immunopathology | Molecular and Cellular Neuroscience | Nervous System Diseases

Abstract

Multiple Sclerosis (MS) is an inflammatory disease of the Central Nervous System (CNS) that causes the demyelination of nerve cells and destroys oligodendrocytes, neurons and axons. Historically, MS has been thought of as a T cell-mediated autoimmune disease of CNS white matter. However, recent studies have identified gray matter lesions in MS patients, suggesting that CNS antigens other than myelin proteins may be involved during the MS disease process. We have recently found that T cells targeting astrocyte-specific antigens can drive unique aspects of inflammatory CNS autoimmunity, including the targeting of gray matter and white matter of the brain and inducing heterogeneous clinical disease courses. In addition to being a target of T cells, astrocytes play a critical role in propagating the inflammatory response within the CNS induced NF-kappaB signaling. Here, we will discuss the pathophysiology of CNS inflammation mediated by T cell-glial cell interactions and its contributions to CNS autoimmunity.

Rights and Permissions

Citation: Front Cell Neurosci. 2015 Aug 5;9:295. doi: 10.3389/fncel.2015.00295. eCollection 2015. Link to article on publisher's site

DOI of Published Version

10.3389/fncel.2015.00295

Comments

Copyright © 2015 Huseby, Kamimura, Arima, Parello, Sasaki and Murakami. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Related Resources

Link to Article in PubMed

Keywords

T cell, astrocytes, autoimmunity, cerebellum, experimental autoimmune encephalomyelitis, glial fibrillary acidic protein, multiple sclerosis

Journal/Book/Conference Title

Frontiers in cellular neuroscience

PubMed ID

26300731

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.