UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Publication Date

10-1-2015

Document Type

Article

Disciplines

Genomics

Abstract

Eukaryotic genomes are packaged into an extensively folded state known as chromatin. Analysis of the structure of eukaryotic chromosomes has been revolutionized by development of a suite of genome-wide measurement technologies, collectively termed "epigenomics." We review major advances in epigenomic analysis of eukaryotic genomes, covering aspects of genome folding at scales ranging from whole chromosome folding down to nucleotide-resolution assays that provide structural insights into protein-DNA interactions. We then briefly outline several challenges remaining and highlight new developments such as single-cell epigenomic assays that will help provide us with a high-resolution structural understanding of eukaryotic genomes.

Rights and Permissions

Citation: Genome Res. 2015 Oct;25(10):1482-90. doi: 10.1101/gr.190165.115. Link to article on publisher's site

DOI of Published Version

10.1101/gr.190165.115

Comments

© 2015 Friedman and Rando; Published by Cold Spring Harbor Laboratory Press.

This article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Genome research

PubMed ID

26430158

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

Included in

Genomics Commons

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