Department of Pathology
Medicinal and Pharmaceutical Chemistry | Medicinal-Pharmaceutical Chemistry | Natural Products Chemistry and Pharmacognosy | Pharmacology | Plant Pathology
The antioxidant activity and chlorogenic acid and caffeic acid contents were investigated from different parts of Acanthopanax senticosus and A. koreanum. Antioxidant activity was assessed by various in vitro assays such as DPPH, ABTS, FRAP, reducing power assays and ORAC, and the chlorogenic acid and caffeic acid were validated by HPLC chromatography. Among the various extracts, the fruit extracts of A. senticosus and A. koreanum exhibited strongest antioxidant activities including ABTS, FRAP, reducing power and ORAC, however, strongest DPPH radical scavenging activity was observed from the leaf extract of A. senticosus. In addition, the antioxidant activities of various extracts were correlated with total phenolic and proanthocyanidin contents. The major phenolic contents from various parts of these plants observed that leaf extract of A. senticosus expressed higher levels of chlorogenic acid (14.86 mg/dry weigh g) and caffeic acid (3.09 mg/dry weigh g) than other parts. Therefore, these results suggest that the leaf of A. senticosus may be an excellent natural source for functional foods and pharmaceutical agents, and the validated method was useful for the quality control of A. senticosus.
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Citation: Molecules. 2015 Jul 22;20(7):13281-95. doi: 10.3390/molecules200713281. Link to article on publisher's site
DOI of Published Version
Acanthopanax senticosu, antioxidant activity, caffeic acid, chlorogenic acid, method validation
Molecules (Basel, Switzerland)
Kim, Young-Hyun; Cho, Myoung Lae; Kim, Dan-Bi; Shin, Gi-Hae; Lee, Jin-Ha; Lee, Jong Seok; Park, Sun-Ok; Lee, Sang-Jong; Shin, Hyun Mu; and Lee, Ok-Hwan, "The Antioxidant Activity and Their Major Antioxidant Compounds from Acanthopanax senticosus and A. koreanum" (2015). Open Access Articles. 2577.
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