Department of Medicine, Division of Infectious Diseases and Immunology
Immunity | Immunology of Infectious Disease
Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like receptor (TLR)-induced production of pro-interleukin (IL)-1beta, IL-6, and tumor necrosis factor (TNF)-alpha between 2-month-old infants and adults. TLR 7/8-induced production of pro-IL-1beta and IL-6 in monocytes was lower in 2-month-old infants compared to adults. There was no difference in TLR 7/8-induced production of TNF-alpha. Lower TLR-induced production of pro-IL-1beta and IL-6 in innate immune cells during early infancy likely contributes to suboptimal vaccine responses and infectious diseases susceptibility.
Rights and Permissions
Citation: Libraty DH, Zhang L, Woda M, Acosta LP, Obcena A, et al. (2013) Toll-Like Receptor Induced Pro-Interleukin-1β and Interleukin-6 in Monocytes Are Lower in Healthy Infants Compared to Adults. PLoS ONE 8(10): e78018. doi:10.1371/journal.pone.0078018 Link to article on publisher's site
DOI of Published Version
Libraty, Daniel H.; Zhang, Lei; Woda, Marcia; Acosta, Luz P.; Obcena, Anamae; Brion, Job D.; and Capeding, Rosario Z., "Toll-like receptor induced pro-interleukin-1beta and interleukin-6 in monocytes are lower in healthy infants compared to adults" (2013). Open Access Articles. 2403.