PubMed ID

22769054

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Date

7-6-2012

Document Type

Article

Subjects

Interferon-alpha; Dendritic Cells; Imidazoles

Disciplines

Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences

Abstract

BACKGROUND: Sex differences in response to microbial infections, especially viral ones, may be associated with Toll-like receptor (TLR)-mediated responses by plasmacytoid dendritic cells (pDCs).

RESULTS: In this study, we identified sex differences in human infant pDC interferon-alpha production following challenge with the TLR7/8 agonist R-848. Male pDC responses were significantly lower than those of females during early infancy. This difference may be attributed to the androgen surge experienced by males during the early infancy period. Pretreatment of human pDCs with dihydrotestosterone produced a significant reduction in interferon-alpha production following R-848 challenge.

CONCLUSIONS: Androgen-mediated regulation of pDC TLR7-driven innate immune responses may contribute to the observed sex differences in response to infections during early infancy.

Comments

Citation: BMC Immunol. 2012 Jul 6;13:35. Link to article on publisher's site

© 2012 Wang et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Related Resources

Link to Article in PubMed

 
 

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