UMMS Affiliation

Department of Medicine, Diabetes Division

Date

1-1992

Document Type

Article

Subjects

Animals; Bone Marrow Transplantation; Cell Transplantation; Flow Cytometry; Hematopoietic Cell Growth Factors; Immunotherapy, Adoptive; Male; Rats; Rats, Inbred BUF; Regeneration; Spleen; Stem Cell Factor; Stem Cells; T-Lymphocytes; Thymus Gland; Whole-Body Irradiation

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Cytokine regulation of prethymic T-lymphoid progenitor-cell proliferation and/or differentiation has not been well-defined, although much is known of cytokine regulation of hemopoietic stem- and progenitor-cell development. Here we use a recently identified hemopoietic growth factor, stem-cell factor (SCF) (a form of the c-kit ligand), and a transplant model of thymocyte regeneration to assess the effect of SCF on the in vivo generation of prethymic, thymocyte progenitor-cell activity. We show that recombinant rat SCF (rrSCF164) administered to weanling rats selectively induces an increase in thymocyte progenitor activity in the spleens of treated rats as compared to rats treated with vehicle, polyethylene glycol (PEG)-conjugated rat albumin, or recombinant human granulocyte colony-stimulating factor (rhG-CSF). These data demonstrate that administration of SCF in vivo affects extrathymic-origin thymocyte regenerating cells and may influence, directly or indirectly, early prethymic stages of T-cell lymphopoiesis in addition to its known effect on early stages of myelopoiesis and erythropoiesis.

Rights and Permissions

Citation: Dev Immunol. 1992;3(1):35-44.

Related Resources

Link to Article in PubMed

Journal Title

Developmental immunology

PubMed ID

1285280

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