UMMS Affiliation

Department of Medicine, Division of Gastroenterology

Date

7-2010

Document Type

Article

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

In the multifactorial pathophysiology of alcoholic liver disease (ALD), inflammatory cascade activation plays a central role. Recent studies demonstrated that Toll-like Receptors, the sensors of microbial and endogenous danger signals, are expressed and activated in innate immune cells as well as in parenchymal cells in the liver and thereby contribute to ALD. In this paper, we discuss the importance of gut-derived endotoxin and its recognition by TLR4. The significance of TLR-induced intracellular signaling pathways and cytokine production as well as the contribution of reactive oxygen radicals is evaluated. The contribution of TLR signaling to induction of liver fibrosis and hepatocellular cancer is reviewed in the context of alcohol-induced liver disease.

Rights and Permissions

Citation: Gastroenterol Res Pract. 2010;2010. pii: 710381. Epub 2010 Aug 17. Link to article on publisher's site

DOI of Published Version

10.1155/2010/710381

Related Resources

Link to Article in PubMed

Journal Title

Gastroenterology research and practice

PubMed ID

20827314

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