Title

MicroRNA biogenesis and regulation of bone remodeling

UMMS Affiliation

Department of Cell Biology

Date

5-27-2011

Document Type

Article

Subjects

Bone Remodeling; MicroRNAs; Osteoblasts; Osteoclasts

Disciplines

Cell and Developmental Biology | Life Sciences | Medicine and Health Sciences

Abstract

MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression. This review will highlight our current understanding of miRNA biogenesis and mechanisms of action, and will summarize recent work on the role of miRNAs, including the miR-29 family, in bone remodeling. These studies represent the first steps in demonstrating the importance of miRNAs in the control of osteoblast and osteoclast differentiation and function. An in-depth understanding of the roles of these regulatory RNAs in the skeleton will be critical for the development of new therapeutics aimed at treating bone loss and perhaps facilitating fracture repair.

Comments

Citation: Arthritis Res Ther. 2011 May 27;13(3):220. Link to article on publisher's site

Related Resources

Link to Article in PubMed