Department of Pediatrics; Department of Cell Biology
Adult; Benzofurans; Dioxins; *Environmental Exposure; Environmental Pollutants; Female; Gas Chromatography-Mass Spectrometry; Humans; Longitudinal Studies; Polychlorinated Biphenyls; Russia; Young Adult
Cell Biology | Endocrinology, Diabetes, and Metabolism | Environmental Public Health | Life Sciences | Medicine and Health Sciences | Pediatrics
BACKGROUND: The present study assessed the temporal trend in serum concentrations of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls (PCBs) among residents of a Russian town where levels of these chemicals are elevated due to prior industrial activity.
METHODS: Two serum samples were collected from eight adult women (in 2000 and 2009), and analyzed with gas chromatography-high-resolution mass spectrometry.
RESULTS: The average total toxic equivalency (TEQ) decreased by 30% (from 36 to 25 pg/g lipid), and the average sum of PCB congeners decreased by 19% (from 291 to 211 ng/g lipid). Total TEQs decreased for seven of the eight women, and the sum of PCBs decreased for six of eight women. During this nine year period, larger decreases in serum TEQs and PCBs were found in women with greater increases in body mass index.
CONCLUSIONS: This study provides suggestive evidence that average serum concentrations of dioxins, furans, and PCBs are decreasing over time among residents of this town.
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Citation: Environ Health. 2011 Jun 22;10:62. Link to article on publisher's site
DOI of Published Version
Environmental health : a global access science source
Humblet, Olivier; Sergeyev, Oleg; Altshul, Larisa; Korrick, Susan A.; Williams, Paige L.; Emond, Claude; Birnbaum, Linda S.; Burns, Jane S.; Lee, Mary M.; Revich, Boris; Shelepchikov, Andrey; Feshin, Denis; and Hauser, Russ, "Temporal trends in serum concentrations of polychlorinated dioxins, furans, and PCBs among adult women living in Chapaevsk, Russia: a longitudinal study from 2000 to 2009" (2011). Open Access Articles. 2258.