Department of Microbiology and Physiological Systems; Program in Cell Dynamics
Cell Cycle Checkpoints; Cytokinesis; Actin Cytoskeleton; Protein-Serine-Threonine Kinases; Cell Polarity
Cell and Developmental Biology | Life Sciences | Medicine and Health Sciences
Regulation of cytoskeletal remodeling is essential for cell cycle transitions. In fission yeast two NDR kinase signaling cascades, MOR and SIN, regulate the actin cytoskeleton to promote polarized growth during interphase and cytokinesis respectively. Our understanding of how these signaling pathways are coordinated to assist transition between the two cell-cycle stages is limited. Here, we review work from our laboratory, which reveals that cross talk between the SIN and MOR pathways is required for inhibition of interphase polarity programs during cytokinesis. Given the conservation of NDR kinase signaling pathways, our results may define general mechanisms by which these pathways are coordinated in higher organisms.