PubMed ID
19649322
UMMS Affiliation
Department of Pathology
Date
7-31-2009
Document Type
Article
Subjects
Amino Acid Sequence; Animals; HIV Envelope Protein gp41; Humans; Mice; *Models, Immunological; Molecular Sequence Data; Receptors, Antigen, T-Cell; Receptors, Immunologic; Signal Transduction; Viruses
Disciplines
Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences | Microbiology
Abstract
In this Opinion, based on a novel model of immune signaling, the Signaling Chain HOmoOLigomerization (SCHOOL) model, I suggest specific mechanisms used by different viruses such as human immunodeficiency virus (HIV), cytomegalovirus (CMV), severe acute respiratory syndrome coronavirus (SARS-CoV), herpesvirus saimiri (HVS), human herpesvirus 6 (HHV-6), etc., to modulate the host immune response mediated by members of the family of multichain immune recognition receptors (MIRRs). I also demonstrate how the SCHOOL model, together with the lessons learned from viral pathogenesis, can be used practically for rational drug design and the development of new therapies for immune disorders.
Related Resources
Included in
Immunology and Infectious Disease Commons, Medicine and Health Sciences Commons, Microbiology Commons
Comments
Citation: Sigalov AB (2009) Novel Mechanistic Insights into Viral Modulation of Immune Receptor Signaling. PLoS Pathog 5(7): e1000404. doi:10.1371/journal.ppat.1000404. Link to article on publisher's site
Copyright: © 2009 Alexander B. Sigalov. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.