Department of Pathology
Amino Acid Sequence; Animals; HIV Envelope Protein gp41; Humans; Mice; *Models, Immunological; Molecular Sequence Data; Receptors, Antigen, T-Cell; Receptors, Immunologic; Signal Transduction; Viruses
Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences | Microbiology
In this Opinion, based on a novel model of immune signaling, the Signaling Chain HOmoOLigomerization (SCHOOL) model, I suggest specific mechanisms used by different viruses such as human immunodeficiency virus (HIV), cytomegalovirus (CMV), severe acute respiratory syndrome coronavirus (SARS-CoV), herpesvirus saimiri (HVS), human herpesvirus 6 (HHV-6), etc., to modulate the host immune response mediated by members of the family of multichain immune recognition receptors (MIRRs). I also demonstrate how the SCHOOL model, together with the lessons learned from viral pathogenesis, can be used practically for rational drug design and the development of new therapies for immune disorders.