Title

Inflammasomes: too big to miss

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology; Department of Molecular Genetics and Microbiology

Date

12-4-2009

Document Type

Article

Subjects

Adaptor Proteins, Signal Transducing; Animals; Caspase 1; Humans; Immunity, Innate; Inflammation; Inflammation Mediators; Interleukin-1; Macromolecular Substances; Models, Immunological; Receptors, Immunologic; Signal Transduction

Disciplines

Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences

Abstract

Inflammation is the coordinated immune response to harmful stimuli that appear during infections or after tissue damage. Cells of the innate immune system are the central players in mediating inflammatory tissue responses. These cells are equipped with an array of signaling receptors that detect foreign molecular substances or altered endogenous molecules that appear under situations of stress. This review provides an overview of recent progress in elucidating the molecular mechanisms that lead to inflammatory reactions. We discuss the current knowledge of the mechanisms leading to the activation of cytoplasmic, multimolecular protein complexes, termed "inflammasomes," which regulate the activity of caspase-1 and the maturation and release of IL-1beta.

Rights and Permissions

Citation: J Clin Invest. 2009 Dec;119(12):3502-11. doi: 10.1172/JCI40599. Epub 2009 Dec 1. Link to article on publisher's site

DOI of Published Version

10.1172/JCI40599

Related Resources

Link to Article in PubMed

Journal Title

The Journal of clinical investigation

PubMed ID

19955661