Title

Making synaptic plasticity and memory last: mechanisms of translational regulation

UMMS Affiliation

Program in Molecular Medicine

Date

1-13-2009

Document Type

Article

Subjects

Adaptor Proteins, Signal Transducing; Animals; Hippocampus; Memory; Phosphoproteins; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Synapses

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Synaptic transmission in neurons is a measure of communication at synapses, the points of contact between axons and dendrites. The magnitude of synaptic transmission is a reflection of the strength of these synaptic connections, which in turn can be altered by the frequency with which the synapses are stimulated, the arrival of stimuli from other neurons in the appropriate temporal window, and by neurotrophic factors and neuromodulators. The ability of synapses to undergo lasting biochemical and morphological changes in response to these types of stimuli and neuromodulators is known as synaptic plasticity, which likely forms the cellular basis for learning and memory, although the relationship between any one form synaptic plasticity and a particular type of memory is unclear. RNA metabolism, particularly translational control at or near the synapse, is one process that controls long-lasting synaptic plasticity and, by extension, several types of memory formation and consolidation. Here, we review recent studies that reflect the importance and challenges of investigating the role of mRNA translation in synaptic plasticity and memory formation.

Rights and Permissions

Citation: Genes Dev. 2009 Jan 1;23(1):1-11. Link to article on publisher's site

DOI of Published Version

10.1101/gad.1735809

Related Resources

Link to Article in PubMed

Journal Title

Genes and development

PubMed ID

19136621