Title

Pancreatic neuroendocrine tumors: the impact of surgical resection on survival

UMMS Affiliation

Department of Surgery

Publication Date

1-9-2009

Document Type

Article

Subjects

Aged; Female; Health Planning Guidelines; Humans; Male; Middle Aged; Neoplasm Staging; Neuroendocrine Tumors; Pancreatic Neoplasms; Prognosis; Risk Factors; SEER Program; Survival Rate; Treatment Outcome

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

BACKGROUND: Although surgical resection is generally recommended for patients with localized pancreatic neuroendocrine tumors (PNETs), the impact of resection on overall survival is unknown. The authors investigated the survival advantage of pancreatic resection using a national database.

METHODS: This is a retrospective survival analysis of patients with PNETs from the Surveillance, Epidemiology, and End Results database (1988-2002).

RESULTS: A total of 728 patients with PNETs were identified with a median survival of 43 months using Kaplan-Meier survival methods. Resection of tumor was associated with significantly improved survival compared with those patients who were recommended for but did not undergo resection (114 months vs 35 months; P < .0001). This survival benefit was demonstrated for patients with localized, regional, and metastatic disease. A multivariable Cox proportional hazards model was constructed to assess the overall effect of surgical resection on survival, and demonstrated an adjusted odds ratio of 0.48 (95% confidence interval, 0.35-0.66) compared with those who were recommended for surgery but did not proceed to surgery.

CONCLUSIONS: The authors have demonstrated in a large national study that resection of primary tumor in patients with PNETs is associated with improved survival across all disease stages. Patients with localized, regional, and metastatic PNETs who are reasonable operative candidates should be considered for resection of their primary tumors.

Rights and Permissions

Citation: Cancer. 2009 Feb 15;115(4):741-51. Link to article on publisher's site

DOI of Published Version

10.1002/cncr.24065

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Cancer

PubMed ID

19130464