Title

Genome-wide views of chromatin structure

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Date

3-26-2009

Document Type

Article

Subjects

Animals; Chromatin; Chromatin Assembly and Disassembly; Gene Expression; *Genome; Genome, Human; Humans; Saccharomyces cerevisiae

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Eukaryotic genomes are packaged into a nucleoprotein complex known as chromatin, which affects most processes that occur on DNA. Along with genetic and biochemical studies of resident chromatin proteins and their modifying enzymes, mapping of chromatin structure in vivo is one of the main pillars in our understanding of how chromatin relates to cellular processes. In this review, we discuss the use of genomic technologies to characterize chromatin structure in vivo, with a focus on data from budding yeast and humans. The picture emerging from these studies is the detailed chromatin structure of a typical gene, where the typical behavior gives insight into the mechanisms and deep rules that establish chromatin structure. Important deviation from the archetype is also observed, usually as a consequence of unique regulatory mechanisms at special genomic loci. Chromatin structure shows substantial conservation from yeast to humans, but mammalian chromatin has additional layers of complexity that likely relate to the requirements of multicellularity such as the need to establish faithful gene regulatory mechanisms for cell differentiation.

Rights and Permissions

Citation: Annu Rev Biochem. 2009;78:245-71. Link to article on publisher's site

DOI of Published Version

10.1146/annurev.biochem.78.071107.134639

Related Resources

Link to Article in PubMed

Journal Title

Annual review of biochemistry

PubMed ID

19317649