Title
Hepatitis C and innate immunity: recent advances
PubMed ID
18625434
UMMS Affiliation
Department of Medicine, Division of Gastroenterology
Date
8-2008
Document Type
Article
Subjects
Animals; Hepacivirus; Hepatitis C; Humans; Immunity, Innate; Lymphocyte Activation; T-Lymphocytes
Disciplines
Gastroenterology | Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences
Abstract
Eradication of hepatitis C virus (HCV) infection requires a complex and coordinated interplay between innate and adaptive immune responses that, when it fails, leads to chronic infection. In this review, the innate immune mechanisms by which HCV is sensed and by which HCV undermines host defense are discussed. The critical role of dendritic cells in antigen presentation and T-cell activation in addition to type I interferon production and interference of HCV with innate immune cell functions are reviewed. Finally, current and emerging therapeutic approaches targeting innate immune pathways are evaluated.
Rights and Permissions
Citation: Clin Liver Dis. 2008 Aug;12(3):675-92, x. Link to article on publisher's site