Hepatitis C and innate immunity: recent advances

UMMS Affiliation

Department of Medicine, Division of Gastroenterology



Document Type



Animals; Hepacivirus; Hepatitis C; Humans; Immunity, Innate; Lymphocyte Activation; T-Lymphocytes


Gastroenterology | Immunology and Infectious Disease | Life Sciences | Medicine and Health Sciences


Eradication of hepatitis C virus (HCV) infection requires a complex and coordinated interplay between innate and adaptive immune responses that, when it fails, leads to chronic infection. In this review, the innate immune mechanisms by which HCV is sensed and by which HCV undermines host defense are discussed. The critical role of dendritic cells in antigen presentation and T-cell activation in addition to type I interferon production and interference of HCV with innate immune cell functions are reviewed. Finally, current and emerging therapeutic approaches targeting innate immune pathways are evaluated.

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Citation: Clin Liver Dis. 2008 Aug;12(3):675-92, x. Link to article on publisher's site

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