Title
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
PubMed ID
19056984
UMMS Affiliation
Howard Hughes Medical Institute; Program in Molecular Medicine
Date
12-6-2008
Document Type
Article
Subjects
Adipocytes; Adipose Tissue; Animals; Dietary Fats; Enzyme Activation; Glucose; Insulin; Insulin Receptor Substrate Proteins; *Insulin Resistance; Interleukin-6; Liver; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 8; Phosphorylation; Proto-Oncogene Proteins c-akt; *Signal Transduction; *Stress, Physiological; Suppressor of Cytokine Signaling Proteins
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
A high-fat diet causes activation of the regulatory protein c-Jun NH2-terminal kinase 1 (JNK1) and triggers development of insulin resistance. JNK1 is therefore a potential target for therapeutic treatment of metabolic syndrome. We explored the mechanism of JNK1 signaling by engineering mice in which the Jnk1 gene was ablated selectively in adipose tissue. JNK1 deficiency in adipose tissue suppressed high-fat diet-induced insulin resistance in the liver. JNK1-dependent secretion of the inflammatory cytokine interleukin-6 by adipose tissue caused increased expression of liver SOCS3, a protein that induces hepatic insulin resistance. Thus, JNK1 activation in adipose tissue can cause insulin resistance in the liver.
Rights and Permissions
Citation: Science. 2008 Dec 5;322(5907):1539-43. Link to article on publisher's site