Title

A stress signaling pathway in adipose tissue regulates hepatic insulin resistance

PubMed ID

19056984

UMMS Affiliation

Howard Hughes Medical Institute; Program in Molecular Medicine

Date

12-6-2008

Document Type

Article

Subjects

Adipocytes; Adipose Tissue; Animals; Dietary Fats; Enzyme Activation; Glucose; Insulin; Insulin Receptor Substrate Proteins; *Insulin Resistance; Interleukin-6; Liver; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 8; Phosphorylation; Proto-Oncogene Proteins c-akt; *Signal Transduction; *Stress, Physiological; Suppressor of Cytokine Signaling Proteins

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

A high-fat diet causes activation of the regulatory protein c-Jun NH2-terminal kinase 1 (JNK1) and triggers development of insulin resistance. JNK1 is therefore a potential target for therapeutic treatment of metabolic syndrome. We explored the mechanism of JNK1 signaling by engineering mice in which the Jnk1 gene was ablated selectively in adipose tissue. JNK1 deficiency in adipose tissue suppressed high-fat diet-induced insulin resistance in the liver. JNK1-dependent secretion of the inflammatory cytokine interleukin-6 by adipose tissue caused increased expression of liver SOCS3, a protein that induces hepatic insulin resistance. Thus, JNK1 activation in adipose tissue can cause insulin resistance in the liver.

Rights and Permissions

Citation: Science. 2008 Dec 5;322(5907):1539-43. Link to article on publisher's site

Related Resources

Link to Article in PubMed