UMMS Affiliation

Program in Cell Dynamics; Department of Biochemistry and Molecular Pharmacology

Date

3-19-2008

Document Type

Article

Subjects

Actins; Animals; Cell Nucleolus; Cell Nucleus; Humans; Microfilaments; Polymers; RNA Polymerase I; RNA, Ribosomal

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The idea that actin may have an important function in the nucleus has undergone a rapid transition from one greeted with skepticism to a now rapidly advancing research field. Actin has now been implicated in transcription by all three RNA polymerases, but the structural form it adopts in these processes remains unclear. Recently, a claim was made that monomeric nuclear actin plays a role in signal transduction, while a just-published study of RNA polymerase I transcription has implicated polymeric actin, consorting with an isoform of its classical partner myosin. Both studies are critically discussed here, and although there are several issues to be resolved, it now seems reasonable to start thinking about functions for both monomeric and assembled actin in the nucleus.

Rights and Permissions

Citation: J Cell Biol. 2008 Mar 24;180(6):1061-4. Epub 2008 Mar 17. Link to article on publisher's site

DOI of Published Version

10.1083/jcb.200709082

Related Resources

Link to Article in PubMed

Journal Title

The Journal of cell biology

PubMed ID

18347069

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.