Title

Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit

UMMS Affiliation

Department of Neurology

Date

8-13-2008

Document Type

Article

Subjects

Brain Diseases; Calcium; Dantrolene; Humans; *Intensive Care; Muscle Relaxants, Central; Ryanodine Receptor Calcium Release Channel

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Calcium plays a central role in neuronal function and injury. Dantrolene, an inhibitor of the ryanodine receptor, inhibits intracellular calcium release from the sarco-endoplasmic reticulum. We review the available data of dantrolene as a potential neuroprotective agent and briefly summarize its other pharmacologic effects that may have potential applications for patients in the neurointensive care unit (NICU). Areas with the need for continued research are identified.

Rights and Permissions

Citation: Neurocrit Care. 2009;10(1):103-15. Epub 2008 Aug 12. Link to article on publisher's site

DOI of Published Version

10.1007/s12028-008-9133-4

Related Resources

Link to Article in PubMed

Journal Title

Neurocritical care

PubMed ID

18696266