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Open Access Articles

Title

Epigenetics in the nervous system

PubMed ID

19005036

Authors

Yan Jiang, University of Massachusetts Medical School
Brett Langley, Weill Medical College of Cornell University
Farah D. Lubin, University of Alabama at Birmingham
William Renthal, University of Massachusetts Medical School
Marcelo A. Wood, University of California, Irvine
Dag H. Yasui, University of California, Davis
Arvind Kumar, The University of Texas Southwestern Medical Center
Eric J. Nestler, The University of Texas Southwestern Medical Center
Schahram Akbarian, University of Massachusetts Medical School
Andrea C. Beckel-Mitchener, National Institutes of Health

UMMS Affiliation

Brudnick Neuropsychiatric Research Institute; Department of Psychiatry

Date

11-14-2008

Document Type

Article

Subjects

Animals; Brain Diseases; Chromatin; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Genetic Predisposition to Disease; Histone Deacetylases; Histones; Humans; Nervous System

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

It is becoming increasingly clear that epigenetic modifications are critical factors in the regulation of gene expression. With regard to the nervous system, epigenetic alterations play a role in a diverse set of processes and have been implicated in a variety of disorders. Gaining a more complete understanding of the essential components and underlying mechanisms involved in epigenetic regulation could lead to novel treatments for a number of neurological and psychiatric conditions.