Title
Paramyxoviruses: different receptors - different mechanisms of fusion
PubMed ID
18346895
UMMS Affiliation
Department of Molecular Genetics and Microbiology
Date
3-19-2008
Document Type
Article
Subjects
Animals; Binding Sites; HN Protein; Hemagglutinins, Viral; Humans; Measles virus; *Membrane Fusion; Newcastle disease virus; Receptors, Virus; Viral Proteins
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
Paramyxovirus-mediated membrane fusion usually requires an interaction between the viral-attachment and -fusion proteins. The mechanism by which this interaction regulates fusion differs between paramyxoviruses that bind to sialic acid-containing receptors and those that recognize specific proteins. The recently solved structure of the globular head of the measles virus hemagglutinin suggests that this difference might be related to the location of the receptor-binding sites on the attachment proteins of the two classes of paramyxoviruses.
Rights and Permissions
Citation: Trends Microbiol. 2008 Apr;16(4):135-7. Epub 2008 Mar 17. Link to article on publisher's site
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