Title

Paramyxoviruses: different receptors - different mechanisms of fusion

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Date

3-19-2008

Document Type

Article

Subjects

Animals; Binding Sites; HN Protein; Hemagglutinins, Viral; Humans; Measles virus; *Membrane Fusion; Newcastle disease virus; Receptors, Virus; Viral Proteins

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Paramyxovirus-mediated membrane fusion usually requires an interaction between the viral-attachment and -fusion proteins. The mechanism by which this interaction regulates fusion differs between paramyxoviruses that bind to sialic acid-containing receptors and those that recognize specific proteins. The recently solved structure of the globular head of the measles virus hemagglutinin suggests that this difference might be related to the location of the receptor-binding sites on the attachment proteins of the two classes of paramyxoviruses.

Rights and Permissions

Citation: Trends Microbiol. 2008 Apr;16(4):135-7. Epub 2008 Mar 17. Link to article on publisher's site

DOI of Published Version

10.1016/j.tim.2008.01.006

Related Resources

Link to Article in PubMed

Journal Title

Trends in microbiology

PubMed ID

18346895