Department of Cancer Biology and Cancer Center
Animals; Antineoplastic Agents; Clinical Trials as Topic; Disease Progression; Gene Expression Regulation, Neoplastic; Humans; Integrins; Male; Neoplasm Metastasis; Neovascularization, Pathologic; Prostatic Neoplasms; Tumor Burden
Life Sciences | Medicine and Health Sciences
Integrins, which are transmembrane receptors for extracellular matrix proteins, play a key role in cell survival, proliferation, migration, gene expression, and activation of growth factor receptors. Their functions and expression are deregulated in several types of cancer, including prostate cancer. In this article, we review the role of integrins in prostate cancer progression and their potential as therapeutic targets.
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Citation: Endocr Relat Cancer. 2008 Sep;15(3):657-64. Epub 2008 Jun 4. Link to article on publisher's site