T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't
Department of Medicine, Division of Gastroenterology
Animals; Hepacivirus; Hepatitis C; Humans; Immunity, Cellular; T-Lymphocytes, Regulatory; Viral Core Proteins
Life Sciences | Medicine and Health Sciences
The mechanism behind the apparent lack of effective antiviral immune response in patients with chronic hepatitis C virus (HCV) infection is poorly understood. Although multiple levels of abnormalities have been identified in innate and adaptive immunity, it remains unclear if any of the subpopulations of T cells with regulatory capacity (Tregs) contribute to the induction and maintenance of HCV persistence. In this review, we summarize the current knowledge about Tregs as they relate to HCV infection.
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Citation: J Leukoc Biol. 2008 Sep;84(3):614-22. Epub 2008 May 21. Link to article on publisher's site