Title

T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't

UMMS Affiliation

Department of Medicine, Division of Gastroenterology

Publication Date

5-23-2008

Document Type

Article

Subjects

Animals; Hepacivirus; Hepatitis C; Humans; Immunity, Cellular; T-Lymphocytes, Regulatory; Viral Core Proteins

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The mechanism behind the apparent lack of effective antiviral immune response in patients with chronic hepatitis C virus (HCV) infection is poorly understood. Although multiple levels of abnormalities have been identified in innate and adaptive immunity, it remains unclear if any of the subpopulations of T cells with regulatory capacity (Tregs) contribute to the induction and maintenance of HCV persistence. In this review, we summarize the current knowledge about Tregs as they relate to HCV infection.

Rights and Permissions

Citation: J Leukoc Biol. 2008 Sep;84(3):614-22. Epub 2008 May 21. Link to article on publisher's site

DOI of Published Version

10.1189/jlb.1107770

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Journal of leukocyte biology

PubMed ID

18495782