Title
T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't
PubMed ID
18495782
UMMS Affiliation
Department of Medicine, Division of Gastroenterology
Date
5-23-2008
Document Type
Article
Subjects
Animals; Hepacivirus; Hepatitis C; Humans; Immunity, Cellular; T-Lymphocytes, Regulatory; Viral Core Proteins
Disciplines
Life Sciences | Medicine and Health Sciences
Abstract
The mechanism behind the apparent lack of effective antiviral immune response in patients with chronic hepatitis C virus (HCV) infection is poorly understood. Although multiple levels of abnormalities have been identified in innate and adaptive immunity, it remains unclear if any of the subpopulations of T cells with regulatory capacity (Tregs) contribute to the induction and maintenance of HCV persistence. In this review, we summarize the current knowledge about Tregs as they relate to HCV infection.
Rights and Permissions
Citation: J Leukoc Biol. 2008 Sep;84(3):614-22. Epub 2008 May 21. Link to article on publisher's site
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