Title

Gene regulation in the third dimension

UMMS Affiliation

Program in Gene Function and Expression; Department of Biochemistry and Molecular Pharmacology

Date

3-29-2008

Document Type

Article

Subjects

Animals; Cell Nucleus; Chromosomes; Chromosomes, Human; Epigenesis, Genetic; *Gene Expression Regulation; Humans; Models, Genetic; Regulatory Elements, Transcriptional; Regulatory Sequences, Ribonucleic Acid

Disciplines

Genetics and Genomics | Life Sciences | Medicine and Health Sciences

Abstract

Analysis of the spatial organization of chromosomes reveals complex three-dimensional networks of chromosomal interactions. These interactions affect gene expression at multiple levels, including long-range control by distant enhancers and repressors, coordinated expression of genes, and modification of epigenetic states. Major challenges now include deciphering the mechanisms by which loci come together and understanding the functional consequences of these often transient associations.

Rights and Permissions

Citation: Science. 2008 Mar 28;319(5871):1793-4. Link to article on publisher's site

DOI of Published Version

10.1126/science.1152850

Related Resources

Link to Article in PubMed

Journal Title

Science (New York, N.Y.)

PubMed ID

18369139