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Open Access Articles

Title

Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine

PubMed ID

18339461

Authors

Mary Dawn T. Co, University of Massachusetts Medical School
Laura Orphin, University of Massachusetts Medical School
John Cruz, University of Massachusetts Medical School
Pamela P. Pazoles, University of Massachusetts Medical School
Alan L. Rothman, University of Massachusetts Medical School
Francis A. Ennis, University of Massachusetts Medical School
Masanori Terajima, University of Massachusetts Medical School

UMMS Affiliation

Center for Infectious Disease and Vaccine Research

Date

3-15-2008

Document Type

Article

Subjects

Adult; Antibodies, Viral; Antibody Specificity; Antigens, CD45; Antigens, CD8; Female; Humans; Immunologic Memory; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza Vaccines; Influenza, Human; Interferon-gamma; Lymphocyte Count; Male; Neutralization Tests; T-Cell Antigen Receptor Specificity; T-Lymphocytes; *Vaccination

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Thirty adults were tested for humoral and cellular immune responses following immunization with the trivalent inactivated influenza vaccine. Modest but significant inverse correlations between the baseline and the fold changes in the number of IFNgamma-producing cells and the levels of neutralizing antibodies were observed. Specific increases in proliferative responses in the CD8 CD45RA+ population were noted after vaccination. Minimal correlations between neutralizing antibody titers and the number of IFNgamma-producing cells in terms of prevaccination levels or fold increases were observed. These results show specific increases in a CD8 T cell subset and discordant T and B responses induced by the trivalent inactivated influenza vaccine.