UMMS Affiliation

Department of Medicine; Department of Infectious Diseases; Graduate School of Nursing; Center for Infectious Disease and Vaccine Research; Department of Pediatrics

Date

2-1-1993

Document Type

Article

Subjects

Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Female; HIV Infections; HIV-1; Half-Life; Humans; Intestinal Absorption; Male; Middle Aged; Nevirapine; Pyridines

Disciplines

Infectious Disease | Medical Microbiology | Nursing | Pediatrics

Abstract

Nevirapine, a nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase, was administered for the first time to humans in a pilot study designed to investigate the pharmacokinetics and tolerance of the drug following single-dose administration to 21 HIV-1-infected individuals. The study followed a parallel design. Different groups of three subjects each were given one of seven dose levels (2.5 to 400 mg) in sequential order, starting with the lowest dose. Each subject received only one dose. Nevirapine was rapidly absorbed at all doses from a tablet formulation. Peak concentrations in plasma were generally achieved within 90 min of dose administration. Secondary peaks were also noted between 3 and 12 h or between 24 and 28 h, the latter being noted mainly in subjects receiving the higher doses. After 24 h, concentrations in plasma declined in a log-linear fashion. The terminal half-life and mean residence time exceeded 24 h in all but one subject, indicating a prolonged disposition time in this population. Both peak concentrations in plasma and areas under the plasma concentration-time curves increased proportionally with increasing dose from 2.5 to 200 mg; however, the increase in the peak concentration in plasma and the area under the plasma concentration-time curve appeared to be less than proportional at the 400-mg dose level in this small number of subjects. This observation may be due to increased clearance or decreased absorption at the highest dose or population differences in absorption or clearance between doses. Studies with a cross-over design are planned to resolve these issues. The pharmacokinetic characteristics of nevirapine are appropriate for once-daily administration. A daily 12.5-mg dose is predicted to achieve trough concentrations in plasma in the range required to totally inhibit replication of wild-type HIV-1 in human T-cell culture.

Rights and Permissions

Citation: Antimicrob Agents Chemother. 1993 Feb;37(2):178-82.

Related Resources

Link to article in PubMed

Journal Title

Antimicrobial agents and chemotherapy

PubMed ID

8452345

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