UMMS Affiliation

University of Massachusetts Medical Center

Date

4-1-1996

Document Type

Article

Subjects

Anti-Bacterial Agents; Chloramphenicol; *Drug Resistance, Microbial; Erythromycin; Humans; Microbial Sensitivity Tests; Penicillins; Streptococcus; Tetracyclines; United States

Disciplines

Medical Microbiology

Abstract

Three hundred fifty-two blood culture isolates of viridans group streptococci obtained from 43 U.S. medical centers during 1993 and 1994 were characterized. Included were 48 isolates of "Streptococcus milleri," 219 S. mitis isolates, 29 S. salivarius isolates, and 56 S. sanguis isolates. High-level penicillin resistance (MIC, > or = 4.0 micrograms/ml) was noted among 13.4% of the strains; for 42.9% of the strains, penicillin MICs were 0.25 to 2.0 micrograms/ml (i.e., intermediate resistance). In general, amoxicillin was slightly more active than penicillin. The rank order of activity for five cephalosporins versus viridans group streptococci was cefpodoxime = ceftriaxone > cefprozil = cefuroxime >> cephalexin. The percentages of isolates resistant (MIC, > or = 2 micrograms/ml) to these agents were 15, 17, 18, 20, and 96, respectively. The rates of resistance to erythromycin, tetracycline, and trimethoprim-sulfamethoxazole were 12 to 38%. Resistance to either chloramphenicol or ofloxacin was uncommon (i.e., < 1%). In general, among the four species, S. mitis was the most resistant and "S. milleri" was the most susceptible.

Rights and Permissions

Citation: Antimicrob Agents Chemother. 1996 Apr;40(4):891-4.

Related Resources

Link to article in PubMed

Journal Title

Antimicrobial agents and chemotherapy

PubMed ID

8849246

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