UMMS Affiliation

Clinical Microbiology Laboratories

Date

7-1-1997

Document Type

Article

Subjects

Anti-Infective Agents; *Aza Compounds; *Fluoroquinolones; Haemophilus influenzae; Microbial Sensitivity Tests; Moraxella (Branhamella) catarrhalis; *Quinolines; Quinolones; Streptococcus pneumoniae

Disciplines

Microbiology

Abstract

The in vitro activity of a novel 8-methoxyquinolone, BAY 12-8039, against recent clinical isolates of Streptococcus pneumoniae (n = 404), Haemophilus influenzae (n = 330), and Moraxella catarrhalis (n = 250) was evaluated. Activity was compared to those of six other fluoroquinolones: ciprofloxacin, clinafloxacin, levofloxacin, ofloxacin, sparfloxacin and trovafloxacin. BAY 12-8039 and clinafloxacin had the highest levels of activity against S. pneumoniae, both with a MIC at which 90% of the isolates were inhibited (MIC90) of 0.06 microg/ml. Trovafloxacin and sparfloxacin were the next most active agents versus S. pneumoniae (MIC90s = 0.12 microg/ml). No differences in activity against penicillin-susceptible, -intermediate, or -resistant strains of S. pneumoniae were noted for any of the fluoroquinolones tested. MIC90s for the seven fluoroquinolones ranged from 0.008 to 0.06 microg/ml versus H. influenzae and from 0.008 to 0.12 microg/ml for M. catarrhalis. The MICs for two strains of S. pneumoniae and one strain of H. influenzae were noted to be higher than those for the general population of organisms for all of the fluoroquinolones tested. Finally, the activity of BAY 12-8039 versus S. pneumoniae was found to be diminished when MIC determinations were performed with incubation of agar dilution plates or broth microdilution trays in 5 to 7% CO2 versus ambient air.

Rights and Permissions

Citation: Antimicrob Agents Chemother. 1997 Jul;41(7):1594-7.

Related Resources

Link to article in PubMed

Journal Title

Antimicrobial agents and chemotherapy

PubMed ID

9210692

Included in

Microbiology Commons

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