Title

Laparoscopic surgery and the systemic immune response

UMMS Affiliation

Department of Surgery

Date

4-4-1998

Document Type

Article

Subjects

Carbon Dioxide; Humans; *Immunity; Interleukin-6; *Laparoscopy; Leukocyte Count; Macrophage Activation; Neoplasms; Peritoneum; Pneumoperitoneum, Artificial

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

OBJECTIVE: The authors review studies relating to the immune responses evoked by laparoscopic surgery. SUMMARY BACKGROUND DATA: Laparoscopic surgery has gained rapid acceptance based on clinical grounds. Patients benefit from faster recovery, decreased pain, and quicker return to normal activities. Only more recently have attempts been made to identify the metabolic and immune responses that may underlie this clinical success. The immune responses to laparoscopy are now being evaluated in relation to the present knowledge of immune responses to traditional laparotomy and surgery in general. METHODS: A review of the published literature of the immune and metabolic responses to laparoscopy was performed. Laparoscopic surgery is compared with the traditional laparotomy on the basis of local and systemic immune responses and patterns of tumor growth. The impact of pneumoperitoneum and insufflation gases on the immune response is also reviewed. CONCLUSIONS: The systemic immune responses for surgery in general may not apply to laparoscopic surgery. The body's response to laparoscopy is one of lesser immune activation as opposed to immunosuppression.

Rights and Permissions

Citation: Ann Surg. 1998 Mar;227(3):326-34.

Related Resources

Link to article in PubMed

Journal Title

Annals of surgery

PubMed ID

9527054