SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor

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Departments of Pharmacology and Molecular Toxicology

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Amino Acid Sequence; Animals; Cloning, Molecular; DNA-Binding Proteins; Gene Library; Hela Cells; Humans; Mice; Molecular Sequence Data; Nuclear Proteins; Protein Isoforms; Recombinant Proteins; Repressor Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Transcription, Genetic; Transfection


Life Sciences | Medicine and Health Sciences


SMRT (silencing mediator for retinoid and thyroid hormone receptors) and N-CoR (nuclear receptor copressor) mediate transcriptional repression of important regulators that are involved in many signaling pathways. SMRT and N-CoR are related proteins that form complexes with mSin3A/B and histone deacetylases to induce local chromatin condensation and transcriptional repression. However, SMRT is substantially smaller than N-CoR, lacking an N-terminal domain of approximately 1,000 aa that are present in N-CoR. Here, we report the identification of SMRT-extended (SMRTe), which contains an N-terminal sequence that shows striking similarity with N-CoR. As in N-CoR, this SMRTe-N-terminal domain also represses basal transcription. We find that SMRTe expression is regulated during cell cycle progression and SMRTe transcripts are present in many embryonic tissues. These data redefine a structurally and functionally more related nuclear receptor corepressor family and suggest an additional role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways.

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Citation: Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3519-24.

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Proceedings of the National Academy of Sciences of the United States of America

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