Think globally, translate locally: what mitotic spindles and neuronal synapses have in common
Department of Molecular Genetics and Microbiology
Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Dendrites; Embryo, Nonmammalian; Female; Genomic Imprinting; Mammals; Mitotic Spindle Apparatus; Neuronal Plasticity; Neurons; RNA, Messenger; Synapses; Xenopus laevis
Life Sciences | Medicine and Health Sciences
Early metazoan development is programmed by maternal mRNAs inherited by the egg at the time of fertilization. These mRNAs are not translated en masse at any one time or at any one place, but instead their expression is regulated both temporally and spatially. Recent evidence has shown that one maternal mRNA, cyclin B1, is concentrated on mitotic spindles in the early Xenopus embryo, where its translation is controlled by CPEB (cytoplasmic polyadenylation element binding protein), a sequence-specific RNA binding protein. Disruption of the spindle-associated translation of this mRNA results in a morphologically abnormal mitotic apparatus and inhibited cell division. Mammalian neurons, particularly in the synapto-dendritic compartment, also contain localized mRNAs such as that encoding alpha-CaMKII. Here, synaptic activation drives local translation, an event that is involved in synaptic plasticity and possibly long-term memory storage. Synaptic translation of alpha-CaMKII mRNA also appears to be controlled by CPEB, which is enriched in the postsynaptic density. Therefore, CPEB-controlled local translation may influence such seemingly disparate processes as the cell cycle and synaptic plasticity.
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Citation: Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7069-71. Link to article on publisher's site
DOI of Published Version
Proceedings of the National Academy of Sciences of the United States of America
Richter, Joel D., "Think globally, translate locally: what mitotic spindles and neuronal synapses have in common" (2001). Open Access Articles. 1783.