Title

Think globally, translate locally: what mitotic spindles and neuronal synapses have in common

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Date

6-21-2001

Document Type

Article

Subjects

Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Dendrites; Embryo, Nonmammalian; Female; Genomic Imprinting; Mammals; Mitotic Spindle Apparatus; Neuronal Plasticity; Neurons; RNA, Messenger; Synapses; Xenopus laevis

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Early metazoan development is programmed by maternal mRNAs inherited by the egg at the time of fertilization. These mRNAs are not translated en masse at any one time or at any one place, but instead their expression is regulated both temporally and spatially. Recent evidence has shown that one maternal mRNA, cyclin B1, is concentrated on mitotic spindles in the early Xenopus embryo, where its translation is controlled by CPEB (cytoplasmic polyadenylation element binding protein), a sequence-specific RNA binding protein. Disruption of the spindle-associated translation of this mRNA results in a morphologically abnormal mitotic apparatus and inhibited cell division. Mammalian neurons, particularly in the synapto-dendritic compartment, also contain localized mRNAs such as that encoding alpha-CaMKII. Here, synaptic activation drives local translation, an event that is involved in synaptic plasticity and possibly long-term memory storage. Synaptic translation of alpha-CaMKII mRNA also appears to be controlled by CPEB, which is enriched in the postsynaptic density. Therefore, CPEB-controlled local translation may influence such seemingly disparate processes as the cell cycle and synaptic plasticity.

Rights and Permissions

Citation: Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7069-71. Link to article on publisher's site

DOI of Published Version

10.1073/pnas.111146498

Related Resources

Link to Article in PubMed

Journal Title

Proceedings of the National Academy of Sciences of the United States of America

PubMed ID

11416189