Title

13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice

UMMS Affiliation

E. K. Shriver Center; Brudnick Neuropsychiatric Research Institute; Department of Psychiatry

Date

3-31-2004

Document Type

Article

Subjects

Animals; Cell Division; Hippocampus; Immunohistochemistry; Isotretinoin; Maze Learning; Mice; Receptors, Retinoic Acid

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The active component of the acne drug Accutane is 13-cis-retinoic acid (RA), and it is highly teratogenic for the developing central nervous system. Very little is known, however, regarding the effect of this drug on the adult brain. Regions of the brain that may be susceptible to RA are those that continue to generate new neurons. In the adult mouse, neurogenesis is maintained in the hippocampus and subventricular zone. This report demonstrates that a clinical dose (1 mg/kg/day) of 13-cis-RA in mice significantly reduces cell proliferation in the hippocampus and the subventricular zone, suppresses hippocampal neurogenesis, and severely disrupts capacity to learn a spatial radial maze task. The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA.

Rights and Permissions

Citation: Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5111-6. Epub 2004 Mar 29. Link to article on publisher's site

DOI of Published Version

10.1073/pnas.0306336101

Related Resources

Link to Article in PubMed

Journal Title

Proceedings of the National Academy of Sciences of the United States of America

PubMed ID

15051884