Title

Breast specimen microcalcifications: radiographic validation and pathologic-radiologic correlation

UMMS Affiliation

Department of Radiology

Date

8-1-1991

Document Type

Article

Subjects

Breast; Breast Neoplasms; Calcinosis; Carcinoma; Carcinoma in Situ; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Papillary; Diagnosis, Differential; *Histological Techniques; Humans; *Mammography; Microtomy; Prospective Studies

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

A prospective analysis of specimens from location and biopsy of mammographically suspect microcalcifications in 108 patients was carried out to determine if microcalcifications were lost during histopathologic processing and the clinical relevance of such loss. Nine hundred sixty-eight paraffin blocks were prepared from 425 gross tissue slices containing calcifications identified at radiography of the specimens. Calcium was apparently lost both during preparation of the blocks (13.6%) and after slide preparation (12.6%), for a total possible loss of 26.2%. All specimens demonstrated calcification histologically. One pathology report was amended because of information obtained after recuts, but all cancers were detected on original slides whether or not calcifications were identified initially. The results indicate that, by following the suggestions offered to ensure adequate histopathologic sampling of calcification seen at mammography, most if not all of the calcification present can be detected on the original slide.

Rights and Permissions

Citation: Radiology. 1991 Aug;180(2):397-401.

Related Resources

Link to Article in PubMed

Journal Title

Radiology

PubMed ID

1648756