Department of Molecular Genetics and Microbiology
Amino Acid Sequence; Newcastle disease virus; Peptide Hydrolases; Protein Precursors; Structure-Activity Relationship; Viral Fusion Proteins
Life Sciences | Medicine and Health Sciences
Newcastle disease virus exhibits a wide range of pathogenicity and virulence which, as with all paramyxoviruses, is directly related to the cleavability of a precursor (F0) of the fusion glycoprotein by cellular proteases. Sequence analyses of the cleavage site of several virulent and avirulent isolates of the Newcastle disease virus serotype reveal a correlation between virulence or pathogenicity and a high content of basic amino acid residues at the cleavage site. A similar correlation has been seen for other paramyxoviruses.
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Citation: J Virol. 1988 Jan;62(1):354-6.
Journal of virology
Glickman, Rhona L.; Syddall, Richard J.; Iorio, Ronald M.; Sheehan, John P.; and Bratt, Michael A., "Quantitative basic residue requirements in the cleavage-activation site of the fusion glycoprotein as a determinant of virulence for Newcastle disease virus" (1988). Open Access Articles. 1590.