Department of Pharmacology; Department of Molecular Genetics and Microbiology
Base Sequence; Blotting, Northern; Blotting, Southern; Cloning, Molecular; Collagen; DNA, Viral; Gene Expression; *Genes, Viral; Herpesvirus 2, Saimiriine; Molecular Sequence Data; RNA, Messenger; Restriction Mapping; Sequence Homology, Nucleic Acid; Viral Structural Proteins
Life Sciences | Medicine and Health Sciences
Sequencing demonstrates that the oncogenic regions of a group A strain and a group C strain of herpesvirus saimiri are nonhomologous. A bicistronic viral mRNA from this region is transcribed in tumor cells transformed by a highly oncogenic group C virus. The first open reading frame is homologous to collagen; no such sequences were found in group A or B strains. This is the first report that a virus encodes for sequences similar to those of a connective tissue protein.
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Citation: J Virol. 1990 Jul;64(7):3509-15.
Journal of virology
Geck, Peter; Whitaker, Scott A.; Medveczky, Maria M.; and Medveczky, Peter G., "Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri" (1990). Open Access Articles. 1579.