Department of Molecular Genetics and Microbiology; Department of Pathology; Program in Molecular Medicine
Adenocarcinoma; Animals; Base Sequence; Chick Embryo; Kidney Neoplasms; Molecular Sequence Data; Oncogene Proteins v-erbB; Proto-Oncogene Proteins; Receptor, Epidermal Growth Factor; Retroviridae Proteins, Oncogenic
Life Sciences | Medicine and Health Sciences
Oncogenicity tests have revealed that a nonmutated erbB oncogene induces renal adenocarcinoma in addition to erythroblastosis. The erbB oncogene is a truncated form of the chicken epidermal growth factor receptor that lacks the extracellular ligand-binding domain. Previously, the nonmutated erbB oncogene has been reported to cause only erythroblastosis. The expansion of the disease potential of erbB to additional neoplasms has been associated with mutations (truncations, deletions, and point mutations) within the erbB gene. Our results indicate that a nonmutated virally expressed erbB oncogene (REB-c) causes a 100% incidence of renal neoplasia.
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Citation: J Virol. 1993 Feb;67(2):1132-6.
Journal of virology
Taglienti, Cherie A.; Banner, Barbara F.; Davis, Roger J.; and Robinson, Harriet L., "Induction of renal adenocarcinoma by a nonmutated erbB oncogene" (1993). Open Access Articles. 1560.