UMMS Affiliation

Department of Molecular Genetics and Microbiology; Department of Pathology; Program in Molecular Medicine

Publication Date

2-1-1993

Document Type

Article

Subjects

Adenocarcinoma; Animals; Base Sequence; Chick Embryo; Kidney Neoplasms; Molecular Sequence Data; Oncogene Proteins v-erbB; Proto-Oncogene Proteins; Receptor, Epidermal Growth Factor; Retroviridae Proteins, Oncogenic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Oncogenicity tests have revealed that a nonmutated erbB oncogene induces renal adenocarcinoma in addition to erythroblastosis. The erbB oncogene is a truncated form of the chicken epidermal growth factor receptor that lacks the extracellular ligand-binding domain. Previously, the nonmutated erbB oncogene has been reported to cause only erythroblastosis. The expansion of the disease potential of erbB to additional neoplasms has been associated with mutations (truncations, deletions, and point mutations) within the erbB gene. Our results indicate that a nonmutated virally expressed erbB oncogene (REB-c) causes a 100% incidence of renal neoplasia.

Rights and Permissions

Citation: J Virol. 1993 Feb;67(2):1132-6.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Journal of virology

PubMed ID

8093489

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