Department of Molecular Genetics and Microbiology
Amino Acid Sequence; Molecular Sequence Data; Mutagenesis, Site-Directed; Newcastle disease virus; Structure-Activity Relationship; Viral Fusion Proteins
Life Sciences | Medicine and Health Sciences
Nonconservative mutations were introduced by site-specific mutagenesis into the fusion peptide and the adjacent heptad repeat region of the fusion protein of Newcastle disease virus in order to determine the role of both regions in the fusion activity of the protein. Mutations in both regions that allowed for proper folding and intracellular transport of the protein blocked the fusion activity of the protein when assayed in the presence of the hemagglutinin-neuraminidase protein.
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Citation: J Virol. 1994 Nov;68(11):7654-8.
Journal of virology
Sergel, Theresa A.; McQuain, Cathy; and Morrison, Trudy G., "Mutations in the fusion peptide and heptad repeat regions of the Newcastle disease virus fusion protein block fusion" (1994). Open Access Articles. 1551.