UMMS Affiliation

Department of Pediatrics

Publication Date

12-16-1998

Document Type

Article

Subjects

Acquired Immunodeficiency Syndrome; Anti-HIV Agents; Child, Preschool; *Disease Transmission, Vertical; Drug Therapy, Combination; HIV-1; Humans; Infant; Infant, Newborn; Viremia; *Virus Replication

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.

Rights and Permissions

Citation: J Virol. 1999 Jan;73(1):362-7.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Journal of virology

PubMed ID

9847340

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.