UMMS Affiliation

Department of Pathology; Department of Medicine, Division of Infectious Diseases and Immunology

Publication Date

4-14-2006

Document Type

Article

Subjects

Animals; Cell Line; Herpesviridae Infections; Interferon-alpha; Interferon-beta; Interleukin-18; Killer Cells, Natural; Liver; Lymphocyte Count; Mice; Mice, Inbred C57BL; Mice, Knockout; Muromegalovirus; Spleen; Toll-Like Receptor 2

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Natural killer (NK) cells are essential for the early control of murine cytomegalovirus (MCMV) infection. Here, we demonstrate that toll-like receptor 2 (TLR2) plays a role in the NK cell-mediated control of MCMV. TLR2 knockout (KO) mice had elevated levels of MCMV in the spleen and liver on day 4 postinfection compared to C57BL/6 mice. In vivo depletion of NK cells with anti-NK1.1 antibodies, however, eliminated the differences in viral titers between the two groups, suggesting that the effect of TLR2 on MCMV clearance on day 4 was NK cell mediated. The defect in early antiviral control was associated with a decreased NK cell population in the spleen and liver and reduced amounts of interleukin-18 and alpha/beta interferon secreted in the TLR2 KO mice. Our studies suggest that in addition to the reported involvement of TLR9 and TLR3, TLR2 is also involved in innate immune responses to MCMV infection.

Rights and Permissions

Citation: J Virol. 2006 May;80(9):4286-91. Link to article on publisher's site

DOI of Published Version

10.1128/JVI.80.9.4286-4291.2006

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Journal of virology

PubMed ID

16611887

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