UMMS Affiliation

Howard Hughes Medical Institute, Program in Molecular Medicine

Publication Date

9-22-1999

Document Type

Article

Subjects

*Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Carrier Proteins; Cell Compartmentation; Cloning, Molecular; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 7; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Protein Binding; Protein Structure, Quaternary; Sequence Homology, Amino Acid; Signal Transduction

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Activation of the c-Jun NH(2)-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is mediated by a protein kinase cascade. This signaling mechanism may be coordinated by the interaction of components of the protein kinase cascade with scaffold proteins. The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates signaling by the mixed-lineage kinase (MLK)-->MAP kinase kinase 7 (MKK7)-->JNK pathway. The scaffold proteins JIP1 and JIP2 interact to form oligomeric complexes that accumulate in peripheral cytoplasmic projections extended at the cell surface. The JIP proteins function by aggregating components of a MAP kinase module (including MLK, MKK7, and JNK) and facilitate signal transmission by the protein kinase cascade.

Rights and Permissions

Citation: Mol Cell Biol. 1999 Oct;19(10):7245-54.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Molecular and cellular biology

PubMed ID

10490659

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