UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; Program in Cell Dynamics

Date

12-6-2003

Document Type

Article

Subjects

Animals; Humans; *RNA Interference; RNA Processing, Post-Transcriptional; RNA, Messenger

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

The discoveries of RNA interference and RNA-mediated posttranscriptional gene silencing have opened an unanticipated new window on the regulation of gene expression as well as a facile and highly effective tool for knocking down gene expression in many organisms and cells. In addition, RNA interference and RNA silencing may conceivably be exploited for human therapeutics sometime in the future, possibly bringing greater clinical impact than have the so far disappointing antisense endeavors. This essay summarizes recent developments and offers some personalized perspectives, with emphasis on what we do not yet know.

Rights and Permissions

Citation: Mol Biol Cell. 2004 Feb;15(2):407-10. Epub 2003 Dec 2. Link to article on publisher's site

DOI of Published Version

10.1091/mbc.E03-10-0726

Related Resources

Link to Article in PubMed

Journal Title

Molecular biology of the cell

PubMed ID

14657237

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