UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology; Program in Cell Dynamics

Publication Date

9-9-2005

Document Type

Article

Subjects

Actins; Animals; Cell Nucleus; DNA-Directed RNA Polymerases; Microfilament Proteins; Nuclear Envelope; Nuclear Pore; RNA, Messenger; *Transcription, Genetic

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Within the past two years, actin has been implicated in eukaryotic gene transcription by all three classes of RNA polymerase. Moreover, within just the past year, actin has been identified as a constituent of filaments attached to the nuclear pore complexes and extending into the nucleus. This review summarizes these and other very recent advances in the nuclear actin field and emphasizes the key present issues. On the one hand, we are confronted with a body of evidence for a role of actin in gene transcription but with no known structural basis; on the other hand, there is now evidence for polymeric actin--not likely in the classical F-actin conformation--in the nuclear periphery with no known function. In addition, numerous proteins that interact with either G- or F-actin are increasingly being detected in the nucleus, suggesting that both monomeric and oligomeric or polymeric forms of actin are at play and raising the possibility that the equilibrium between them, perhaps differentially regulated at various intranuclear sites, may be a major determinant of nuclear function.

Rights and Permissions

Citation: Mol Biol Cell. 2005 Nov;16(11):5055-60. Epub 2005 Sep 7. Link to article on publisher's site

DOI of Published Version

10.1091/mbc.E05-07-0656

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Molecular biology of the cell

PubMed ID

16148048

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