Basic science highlights
Program in Molecular Medicine and department of Molecular Genetics and Microbiology
Anti-HIV Agents; HIV-1; Humans; Virus Replication
Life Sciences | Medicine and Health Sciences
The 14th Conference on Retroviruses and Opportunistic Infections generated a lot of excitement with the announcement of clinical studies employing the use of 2 new classes of antiretroviral drugs that target the viral integrase enzyme and the viral coreceptor CCR5. In addition, a number of presentations on cellular restriction factors provided surprises regarding the mechanism by which cellular restrictions antagonize viral infection. There was also much interest in studies presenting novel cellular cofactors of HIV-1 infection. The conference illustrated how basic science research is paying off. Essential steps in the viral life cycle, uncovered through basic research, are now being targeted by new classes of antiviral agents. In addition, basic science is unveiling potential new targets of antiretroviral therapy.
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Citation: Top HIV Med. 2007 Apr-May;15(2):21-5.
Topics in HIV medicine : a publication of the International AIDS Society, USA
Stevenson, Mario, "Basic science highlights" (2007). Open Access Articles. 1366.