Title

Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA

UMMS Affiliation

Department of Medicine, Division of Infectious Diseases and Immunology

Date

3-7-2007

Document Type

Article

Subjects

Animals; Antibodies, Viral; Antigen-Antibody Complex; Cytokines; Dendritic Cells; Enterovirus B, Human; Humans; Membrane Glycoproteins; Mice; Mice, Knockout; Plasma Cells; RNA, Viral; Receptors, Fc; Signal Transduction; Toll-Like Receptor 7

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

TLR7 recognizes the genome of ssRNA viruses such as Coxsackievirus B. Because TLR7 is expressed in intracellular compartments, viral RNA must be internalized before its recognition by TLR7. In this study, we define plasmacytoid dendritic cells (pDC) as peripheral blood mononuclear immune cells that respond to Coxsackievirus. pDC activation by Coxsackievirus B requires the presence of specific antiviral Abs. We show that Fc receptors mediate the recognition of virus-Ab complexes and that TLR7 is required for human and murine pDC production of cytokines. These data define a pathway by which intracellular TLR7 senses viral RNA and indicate a role for TLRs in association with Abs in sustaining virus-specific responses.

Rights and Permissions

Citation: J Immunol. 2007 Mar 15;178(6):3363-7.

Related Resources

Link to Article in PubMed

Journal Title

Journal of immunology (Baltimore, Md. : 1950)

PubMed ID

17339429