UMMS Affiliation

Cancer Center; Department of Cancer Biology; Department of Neurology; Department of Physiology

Publication Date

5-16-2007

Document Type

Article

Subjects

Antigens, CD; Breast Neoplasms; Cell Division; Erythroid Progenitor Cells; Female; Fetal Blood; Growth Substances; Hematopoietic Stem Cells; Hormones; Humans; Infant, Newborn; Insulin-Like Growth Factor I; Pregnancy

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

INTRODUCTION: Prenatal levels of mitogens may influence the lifetime breast cancer risk by driving stem cell proliferation and increasing the number of target cells, and thereby increasing the chance of mutation events that initiate oncogenesis. We examined in umbilical cord blood the correlation of potential breast epithelial mitogens, including hormones and growth factors, with hematopoietic stem cell concentrations serving as surrogates of overall stem cell potential. METHODS: We analyzed cord blood samples from 289 deliveries. Levels of hormones and growth factors were correlated with concentrations of stem cell and progenitor populations (CD34+ cells, CD34+CD38- cells, CD34+c-kit+ cells, and granulocyte-macrophage colony-forming units). Changes in stem cell concentration associated with each standard deviation change in mitogens and the associated 95% confidence intervals were calculated from multiple regression analysis. RESULTS: Cord blood plasma levels of insulin-like growth factor-1 (IGF-1) were strongly correlated with all the hematopoietic stem and progenitor concentrations examined (one standard-deviation increase in IGF-1 being associated with a 15-19% increase in stem/progenitor concentrations, all P < 0.02). Estriol and insulin-like growth factor binding protein-3 levels were positively and significantly correlated with some of these cell populations. Sex hormone-binding globulin levels were negatively correlated with these stem/progenitor pools. These relationships were stronger in Caucasians and Hispanics and were weaker or not present in Asian-Americans and African-Americans. CONCLUSION: Our data support the concept that in utero mitogens may drive the expansion of stem cell populations. The correlations with IGF-1 and estrogen are noteworthy, as both are crucial for mammary gland development.

Rights and Permissions

Citation: Breast Cancer Res. 2007;9(3):R29. Link to article on publisher's site

DOI of Published Version

10.1186/bcr1674

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Breast cancer research : BCR

PubMed ID

17501995

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.