UMMS Affiliation

Program in Molecular Medicine

Publication Date

4-13-2007

Document Type

Article

Subjects

Cell Proliferation; Molecular Structure; Nucleosomes; Polyamines; Saccharomyces cerevisiae; Time Factors

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Polyamines are naturally occurring intracellular polycations that are essential for viability and growth of eukaryotes. Dysregulation of polyamine metabolism is a hallmark of cancer and the carcinogenic process, and consequently development of polyamine analogues has emerged as a viable strategy for therapeutic intervention. Previously, we showed that the naturally occurring polyamines spermidine and spermine were quite effective at inducing the oligomerization of nucleosomal arrays in vitro, suggesting that polyamines may play a key role in regulating higher order chromatin structures in vivo. Here, we analyse the ability of a number of synthetic polyamine analogues to potentiate formation of higher order chromatin structures in vitro. We find that a class of long-chain polyamines called oligoamines are potent inducers of nucleosomal array oligomerization in vitro and that these same polyamine analogues rapidly block yeast cell growth.

Rights and Permissions

Citation: Biochem J. 2007 Aug 1;405(3):541-5. Link to article on publisher's site

DOI of Published Version

10.1042/BJ20061347

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

The Biochemical journal

PubMed ID

17428198

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