Cortical blindness after correction of symptomatic hyponatremia: dynamic cerebral dysfunction visualized using serial SPECT scanning

UMMS Affiliation

Department of Neurology; Department of Radiology

Publication Date


Document Type



Aged; Blindness; Brain; Brain Diseases; *Cerebrovascular Circulation; Female; Humans; Hyponatremia; *Tomography, Emission-Computed, Single-Photon


Life Sciences | Medicine and Health Sciences


A 70-yr-old woman developed cortical blindness after correction of hyponatremia. Regional hyperperfusion was noted on SPECT scans obtained in the acute phase. One month later when symptoms had largely resolved, a repeat examination was normal. This regional hyperperfusion, which was not associated with any apparent structural damage, may have represented either luxury perfusion or a transient increased metabolic requirement of the dysfunctional cortical area. SPECT scanning may be a useful method to study cerebral dysfunction resulting from an osmotic disturbance.

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Citation: J Nucl Med. 1995 Jul;36(7):1272-4.

Related Resources

Link to Article in PubMed

Journal/Book/Conference Title

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

PubMed ID